EFFECTS OF OXYGEN-TENSION AND PH ON THE ULTRASONIC-ABSORPTION PROPERTIES OF SICKLE CELLS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 54  (2) , 451-458
Abstract
The ultrasonic absorption of sickle cells was compared with the morphological changes in these cells as produced by varying O2 tensions and pH. A decrease in O2 tension caused increased sickling and an increase in the ultrasonic absorption of the blood. An increase in pH reduced the ultrasonic absorption and decreased sickling. Ultrasonic absorption can apparently detect changes in the aggregation state of sickle cell Hb in situ within the red cell and this method may be useful in monitoring the degree of sickling under various environmental conditions.

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