Pharmacokinetics of cefoxitin sodium in normal subjects and in uraemic patients

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Abstract
Pharmacokinetics data of cefoxitin sodium were determined in normal subjects and in uraemic patients. All subjects (5 normal and 20 uraemic) received 30 mg/kg of cefoxitin i.v. in 30-min. infusions. In healthy subjects, the serum half-life (T ½ ) was 0.78 ±0.10 h, and the apparent volume of distribution (A.V.D.) was 7.70 1. The mean renal clearance was 329 ml/min/1.73 m 2 .For uremic patients we observed a very sharp increase in T ½ when creatinine clearance fell below 30 ml/min compared to 0.78 h in normal subjects, T ½ was 21.56 h in patients with very poor renal function. During a haemodialysis session the serum levels decreased: 86.3% of the initial serum concentration was extracted.

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