Studies on drug metabolism by use of isotopes. XXI. Synthesis of 3-phenylpropyl carbamate labeled with deuterium and carbon-13, and physicochemical properties of these labeled drugs.

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Abstract
For the investigation of metabolism of 3-phenylpropyl carbamate in man, drugs labeled with 2H and 13C were synthesized. Physicochemical properties of labeled compounds, especially mass spectrometric behavior, were examined. The deuterium-hydrogen exchange reaction was observed in 2H labeled 3-phenylpropyl carbamate but in the case of 13C labeled compounds, there was no isotope effect occurring in mass chamber. Calibration curve for dilution analysis was examined by use of methyl benzoate single-labeled with 13C and linear correlation was obtained between 1 and 300 fold dilutions.