Comparison of Effect of Progesterone and 11-Ketoprogesterone upon Glycosuria of Partially Depancreatized Rat

Abstract
Partially depancreatized force-fed rats were injd. with 1 to 100 mg./day of progesterone and 1-32 mg./day of 11-ketoprogesterone. Very large doses of progesterone caused exacerbation of the diabetes and 11-ketoprogesterone was found to be significantly more potent in this respect. The diabetogenicity of 11-ketoprogesterone is manifest in either the presence or absence of the adrenal glands.

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