Nucleotide Sequence of the ADH23 Gene Encoding the Human Alcohol Dehydrogenase β3 Subunit
- 1 August 1989
- journal article
- research article
- Published by Wiley in Alcohol, Clinical and Experimental Research
- Vol. 13 (4) , 594-596
- https://doi.org/10.1111/j.1530-0277.1989.tb00383.x
Abstract
All nine exons of the ADH23 allele, which encodes the human alcohol dehydrogenase β3 subunit, have been cloned and sequenced. Comparison of this sequence to the ADH21 nucleotide sequence revealed only a single difference that results in an amino acid change, thus proving that the significant kinetic differences between these two isozymes is due to the Cys for Arg substitution at position 369. There are also two silent polymorphisms, and two changes in noncoding regions.This publication has 15 references indexed in Scilit:
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