Comparative Effectiveness of Fresh and Lyophilized Platelets in Controlling Irradiation Hemorrhage in the Rat.

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Abstract
In rats the comparative effectiveness of fresh and lyophilized homologous platelets was evaluated in the control of irradiation induced thrombopenic hemorrhage. Rats were irradiated with 600 r, 250 KVP X-ray to produce marrow aplasia and ultimate thrombopenia. Platelet transfusions were given on the 5th, 7th, and 9th day after irradiation. Fresh platelets resulted in marked elevation of the platelet counts whereas the lyophilized platelets did not circulate. Hematocrit decrease was less in the fresh platelet group. In the lyophilized platelet group the hematocrit decreased more rapidly than in irradiated non-treated group. At the site of minor trauma (saline injection) there were no hematoma in rats receiving fresh platelets but large hematoma developed in the irradiated non-treated and the lyophilized treated group. It is concluded that lyophilized platelets when compared to fresh platelets are ineffective to stop thrombopenic hemorrhage.

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