Transfer of Sodium and Bromide Ions Between Blood, Cerebrospinal Fluid and Brain Tissue

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Abstract
Radioactive Na and Br ions were used to study the transfer of ions between blood, cerebrospinal fluid (CSF) and brain tissue. These predominantly extracellular ions, although opposite in charge, behaved similarly. After intravenous injection of labeled ions their appearance in the CSF followed a single exponential curve. Brain tissue was in equilibrium with CSF at an early time as was the skeletal muscle with serum; however, CSF did not equilibrate with serum even at 16 hours. After intracisternal injection the disappearance of the ions from the CSF was described by 2 exponentials. Their appearance in the serum was calculated to be a single exponential assuming that rate of exit from the CSF was equal to rate of entrance into CSF following intravenous injection. Brain tissue was not in equilibrium with CSF. Similar results were obtained by the simultaneous injections of tracer Br82 intracisternally and Br79 (9.7 meq/kg body weight) intravenously.

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