THE METABOLISM OF HYDROCORTISONE, PREDNISOLONE AND FLUOCORTOLONE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 93  (21) , 671-673
Abstract
The plasma levels of hydrocortisone, prednisolone and fluocortolone were studied in healthy males by a competitive protein-binding technique after separation by TLC. Cortisone showed a mean morning level of 440 nmol/l .+-. 165 nmol/l and a half-life of 4.8 h. The half-life of prednisolone was determined after i.v. injection of 25 mg and was 2.4 h and that of fluocortolone, after oral administration of 60 mg, was 1.7 h.

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