Alcohol Withdrawal: Effects of Clonidine Treatment on Sympathetic Activity, the Renin‐Aldosterone System, and Clinical Symptoms

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Abstract
Twenty male alcoholics with alcohol withdrawal syndrome were randomized to receive either oral clonidine (3-600 .mu.g, 6 hourly) or oral chlormethiazole (500-1000 mg, 6 hourly) for 4 days. All subjects were also given oral carbamazepine (200 mg, 12 hourly) throughout the study. Nine subjects given clonidine and 8 given chlormethiazole completed the study. Clonidine was as effective as chlormethiazole in suppressing the symptoms and signs of alcohol withdrawal. Plasma catecholamines, blood pressure and pulse rate fell more rapidly and to a greater extent during clonidine than following chlormethiazole, findings which could have therapeutic implications. Activation of brain noradrenergic neurons apparently constitute a common denominator in the pathophysiology of several withdrawal syndromes.