Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching
Open Access
- 25 September 2009
- journal article
- Published by Springer Nature in Molecular Brain
- Vol. 2 (1) , 30
- https://doi.org/10.1186/1756-6606-2-30
Abstract
TDP-43 is an evolutionarily conserved RNA-binding protein implicated in the pathogenesis of frontotemporal dementia (FTD), sporadic and familial amyotrophic lateral sclerosis (ALS), and possibly other neurodegenerative diseases. In diseased neurons, TDP-43 is depleted in the nucleus, suggesting a loss-of-function pathogenic mechanism. However, the normal function of TDP-43 in postmitotic neurons is largely unknown.Keywords
This publication has 38 references indexed in Scilit:
- A new subtype of frontotemporal lobar degeneration with FUS pathologyBrain, 2009
- TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase ToxicityJournal of Biological Chemistry, 2009
- Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivoNucleic Acids Research, 2009
- Neurodegenerative Diseases Target Large-Scale Human Brain NetworksNeuron, 2009
- Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 ProteinopathiesJournal of Biological Chemistry, 2009
- Clinical and Pathological Continuum of Multisystem TDP-43 ProteinopathiesArchives of Neurology, 2009
- New approaches to the treatment of frontotemporal lobar degenerationCurrent Opinion in Neurology, 2008
- Molecular and cellular mechanisms of dendritic morphogenesisCurrent Opinion in Neurobiology, 2007
- The Microprocessor complex mediates the genesis of microRNAsNature, 2004
- Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing proteinNature Genetics, 2004