Accessible 5′-end of CpG-containing Phosphorothioate Oligodeoxynucleotides is essential for immunostimulatory activity

This publication has 20 references indexed in Scilit:

• Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity
  Journal of Allergy and Clinical Immunology, 2000
• Antisense therapeutics: is it as simple as complementary base recognition?
  Molecular Medicine Today, 2000
• CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
  The EMBO Journal, 1998
• Mixed Backbone Oligonucleotides: Improvement in Oligonucleotide-induced Toxicity In Vivo
  Antisense and Nucleic Acid Drug Development, 1998
• Pattern and Kinetics of Cytokine Production Following Administration of Phosphorothioate Oligonucleotides in Mice
  Antisense and Nucleic Acid Drug Development, 1997
• Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor‐α‐mediated shock
  European Journal of Immunology, 1997
• 3′-3′-linked oligonucleotides: Synthesis and stability studies
  Bioorganic & Medicinal Chemistry Letters, 1996
• CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.
  Proceedings of the National Academy of Sciences, 1996
• Effect of different chemically modified oligodeoxynucleotides on immune stimulation
  Biochemical Pharmacology, 1996
• CpG motifs in bacterial DNA trigger direct B-cell activation
  Nature, 1995