Dienediolates from unsaturated carboxylic acids. Reaction with para-substituted benzaldehydes. Electronic effects on regioselectivity
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 2,p. 327-332
- https://doi.org/10.1039/p19890000327
Abstract
Regioselectivity α/γ ratios for addition of the lithium dienediolate of crotonic acid to para-substituted benzaldehydes are subject to small electronic effects when reactions are carried out at low temperature, but strong influence by substituents is observed on heating for 1 h at 60 °C. A linear correlation is then found between regiochemical ratios and σp parameters. Stereoselectivity RR/RS ratios (33 : 66 to 43 : 57) for α-adducts obtained in the cold do not depend on the substituents.Keywords
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