Thiolactomycin, a new antibiotic. IV. Biological properties and chemotherapeutic activity in mice.

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Abstract
The new thiolactone antibiotic, thiolactomycin, is rapidly absorbed in rats when administered orally or by i.m. injection. A peak in concentration of the drug is reached in the blood and in various visceral organs within 15 min after administration. The concentration decreases rather rapidly and about 51-69% of the drug is excreted in urine during the first 24 h. Though the in vitro effect of thiolactomycin is moderate, it effectively proctected mice challenged i.p. with several strains of Serratia marcescens and Klebsiella pneumoniae and was more effective than carbenicillin in treating experimental acute urinary tracts infected with S. marcescens. In mice whose immunodefense was decreased by treatment with cyclophosphamide, thiolactomycin was more effective than carbenicillin against S. marcescens challenge.