Quantitative evaluation of exercise-induced ST- segment depression for estimation of degree of coronary artery disease

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Abstract
Comparative analysis of coronary arteriography and exercise ECG recordings of 33 patients with ischae-mic heart disease is presented. Linear regression was found between the increase of heart rate (HR) as well as increase of systolic blood pressure-heart rate product (SBPxHR) and the level of ST-segment depression developing during exercise. A significant correlation was established between the slope of the regression line (i.e. 'm'coefficient of y=mx+b) expressing the rate of change of ST-segment depression and the degree of coronary artery disease confirmed by arteriography. The average value of 'm' coefficients differed significantly according to the number of diseased vesseb (P< 001-0.001). The ratio of maximal ST depression and maximal HR (STmax/HRmax) measured at the end of the exercise indicated reliably the severity of coronary artery disease and is suggested for everyday practice.

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