EFFECTS OF BILATERAL OLFACTORY BULB ABLATIONS ON THE POLYAMINE LEVELS IN RAT BRAIN

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Abstract
Whole brain concentrations of spermidine (SPD) and spermine (SPM) in olfactory bulb (OB) lesioned rats did not show a significant difference when compared with unoperated controls. In unoperated controls, the SPD level displayed considerable regional variation. The lowest concentration was observed in the cortex and the highest in the pons-medulla oblongata. Though the cerebellum contained the 2nd highest level of SPD, its total polyamine was the greatest of all brain regions studied. The cortex, which had the lowest content of SPD, exhibited the second highest level of SPM. The SPD level in the cortex significantly increased in OB lesioned rats compared with that of unoperated controls. The SPM level in the striatum significantly decreased in OB lesioned rats compared with unoperated controls. In the cortex, there was no significant augmentation in the SPM level despite a marked increase in the SPD level.