EFFECTS OF SEX HORMONES UPON BODY GROWTH, SKIN, HAIR AND SEBACEOUS GLANDS IN THE RAT1

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Abstract
The subcut. inj. of 83 7 of estradiol benzoate twice weekly was followed by a marked suppression in the growth of rats. Concurrent adm. of 2.5 mg. of testosterone propionate twice weekly did not offset the stunting of growth in the [female][female], but in [male][male] the stunting was much reduced. Supplementing the colony diet with 1-cystine had no effect upon the growth-suppressing action of the estrogen. Shagginess and marked loss of hair were present in all of the estrogen-treated animals, and regrowth of hair in shaved areas was greatly retarded. Although added dietary cystine did not modify the effect of the estrogen upon the hair, the animals receiving the androgen in addition to the estrogen were completely "protected" against the effects of the estrogen upon the hair. The skin of the estrogen-treated rats was quite thin, with both dermis and epidermis being so affected. The sebaceous glands were much reduced in size and number. Added dietary cystine did not significantly alter these actions of the estrogen. The animals receiving both the androgen and estrogen were completely "protected" against these changes.

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