Combination Antifungal Chemotherapy for Experimental Disseminated Cendidiasis: Lack of Correlation Between in Vitro and in Vivo Observations with Amphotericin Band Rifampin
- 1 July 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 5 (Supplement) , S626-S630
- https://doi.org/10.1093/clinids/5.supplement_3.s626
Abstract
Disseminated candidiasis was established in guinea pigs immunosuppressed with highdose cortisone acetate. After the disease had been characterized by histopathol~g~c study and quantitative culture of selected organs, guinea pigs were given amphote.ncm B alone or in combination with rifampin. The addition of rifampin to the regimen enhanced the in vitro rate of killing of the strain of Candida albicans used in the studies but was not noticeably beneficial in treatment of the disease in guinea pigs. Thus, the demonstration of an enhanced rate of killing in vitro was not a reliable basis for prediction of the response to the drug in vivo.Keywords
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