Forty patients were treated in a double blind study utilizing Hydroxyurea. Those treated with Hydroxyurea, irradiation and surgery achieved complete eradication of tumor. The most notable contribution of Hydroxyurea appeared to be the extensive necrosis, radiation effect, and destruction beyond any recognition of tumor in lymph nodes. Forty-five cases, previous failures to other modalities, were retreated with Hydroxyurea and irradiation with local regression of tumor in all cases.