The effects of level of expression of a jellyfish Shaker potassium channel: a positive potassium feedback mechanism
- 1 May 1999
- journal article
- Published by Wiley in The Journal of Physiology
- Vol. 517 (1) , 25-33
- https://doi.org/10.1111/j.1469-7793.1999.0025z.x
Abstract
1. When jellyfish Shaker potassium channels (jShak2) are heterologously expressed in Xenopus oocytes at different levels they demonstrate density-dependent changes in electrical and kinetic properties of macroscopic currents. 2. The activation and inactivation properties of jShak2 channels depend on the extracellular potassium concentration. In this study we present experimental data which show that expression-dependent changes in kinetic and electrical properties of jShak2 macroscopic currents can be explained by the positive feedback effect of dynamic accumulation of K+ in the perimembranal space.Keywords
This publication has 19 references indexed in Scilit:
- Rapid chemical kinetic techniques for investigations of neurotransmitter receptors expressed in Xenopus oocytesProceedings of the National Academy of Sciences, 1996
- Submicroscopic Ca2+ diffusion mediates inhibitory coupling between individual Ca2+ channelsNeuron, 1992
- Level of expression controls modes of gating of a K+ channelFEBS Letters, 1992
- Extracellular K+ specifically modulates a rat brain K+ channel.Proceedings of the National Academy of Sciences, 1992
- The polarized distribution of poly(A+)-mRNA-induced functional ion channels in the Xenopus oocyte plasma membrane is prevented by anticytoskeletal drugs.The Journal of cell biology, 1991
- TEA prevents inactivation while blocking open K+ channels in human T lymphocytesBiophysical Journal, 1989
- Significant potassium ion accumulation at the external surface of Myxicola giant axonsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1985
- Geometric Parameters of Pipettes and Membrane PatchesPublished by Springer Nature ,1983
- Extracellular Potassium Ions Mediate Specific Neuronal InteractionScience, 1982
- Modulation of Synaptic Transmitter Release by Repetitive Postsynaptic Action PotentialsScience, 1976