Abnormal Ventral Temporal Cortical Activity During Face Discrimination Among Individuals With Autism and Asperger Syndrome

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Abstract
THE SYMPTOMS of autism spectrum disorders, such as a preference for inanimate objects and lack of interest in the human face, are evident as early as the first year of life.1-3 Abnormalities in face-recognition skills are of particular interest, as they may provide clues about the developmental mechanisms involved in the pathobiology of autism and Asperger syndrome (AS). Recognition of individual faces is necessary for successful interpersonal relationships. It has been argued that faces are a special class of object,4,5 and some evidence suggests an innate preference for faces over other objects. For example, newborns preferentially respond to the human face, although this rudimentary skill, or looking preference, must be practiced to develop further.6,7