"Atmospheric" Epoxidation of Benzo[ a ]pyrene by Ozone: Formation of the Metabolite Benzo[ a ]pyrene-4,5-Oxide
- 19 December 1980
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 210 (4476) , 1347-1349
- https://doi.org/10.1126/science.210.4476.1347
Abstract
Benzo[a]pyrene deposited on a glass fiber filter reacts rapidly in the dark or light with ambient levels of ozone to yield a mixture of products that display strong direct mutagenicity in the Ames assay. The major stable contributor to this activity has been identified as benzo[a]pyrene-4,5-oxide, a DNA-binding metabolite in biological systems, known to be a strong direct mutagen with Salmonella typhimurium strain TA98.This publication has 24 references indexed in Scilit:
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