Nucleoside H-Phosphonates. V. The Mechanism of Hydrogenphosphonate Diester Formation Using Acyl Chlorides as Coupling Agents in Oligonucleotide Synthesis by the Hydrogenphosphonate Approach

1 June 1987

journal article
research article
Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids

Vol. 6 (3) , 655-662
https://doi.org/10.1080/07328318708069994

Abstract

The H-phosphono-acyl mixed anhydrides of type III were found to be the main intermediates during H-phosphonate diester formation using acyl chlorides as coupling agents in the reaction of hydrogenphosphonate monoesters with hydroxylic components.