Remarques sur la résistance in vitro des staphylocoques à la rifamycine SV

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Abstract
Using Szybalskl''s gradient technic and the study of the clonal distribution by dilution in gelose, stable mutants 100 times more resistant than the original strain were isolated. Only a single resistant strain, from a patient treated with rifamycin-SV for cholecystitis, was detected out of 300 strains of Staphylococcus studied. A certain number of bacteria (from 1:1000 to 1:10,000) can multiply in concentrations of rifamycin 10 times greater than required to inhibit the growth of the majority of strains. Some of these colonies are mutants stable at apparently variable levels, while others can resume the sensitivity of the original strain after subculturing. The presence of satellitism surrounding these colonies indicates an agent capable of inhibiting rifamycin-SV.

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