STUDIES ON THE CONDITIONS OF ACTIVITY IN ENDOCRINE GLANDS

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Abstract
Asphyxia of the denervated adrenal, induced by compression of the abdominal aorta for 10 sec. causes a discharge of adrenin.The presence of an excess of adrenin in the circulation is shown by a large increase in the rate of the denervated heart in the surviving animal. Cannon''s procedure for dener-vation of the heart and of the glands producing cardiac accelerating hormones was used, with ether anesthesia and strict asepsis. The animals had completely recovered and appeared normal, and since the heart rates were recorded by means of a tambour placed outside the chest wall, no anesthesia was necessary. Demedullation of the adrenal prevents the increase in heart rate after asphyxia. The authors conclude, therefore, that the denervated adrenal medulla can still respond to asphyxial stimulation.

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