Stage-specific expression of a developmentally regulated gene inDirofilaria immitis
- 1 March 1992
- journal article
- research article
- Published by Cambridge University Press (CUP) in Journal of Helminthology
- Vol. 66 (1) , 62-67
- https://doi.org/10.1017/s0022149x00012578
Abstract
A previously reported cDNA clone encoding 34 kDa antigenic polypeptide ofDirofilaria immitis(λ cD34) was studied to elucidate the mechanism of stage-specific gene expression. The 34 kDa polypeptide was a larva-specific antigen and the mRNA was detectable in microfilariae but not in adult worms and eggs. The λ cD34 gene was not sex linked and was contained in the genome ofD. immitisat each stage. The stage-specific expression of the developmentally regulated gene inD. immitismay be controlled primarily at the mRNA level.Keywords
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