Heat shock-induced reactivation of herpes simplex virus type 1 in latently infected mouse trigeminal ganglion cells in dissociated culture

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Abstract
An in vitro herpes simplex virus type 1 (HSV-1) latency model was established, using trigeminal ganglia from latently infected mice. When heat-treated at 43 °C for 3 h, reactivation followed in 76.6% of the cultures, while reactivation was not observed in non-heat-treated controls.
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