Multiple-Dose Nonlinear Regression Analysis Program for the Microcomputer
- 1 March 1984
- journal article
- research article
- Published by Wolters Kluwer Health in Therapeutic Drug Monitoring
- Vol. 6 (1) , 51-58
- https://doi.org/10.1097/00007691-198403000-00010
Abstract
An adaptation of a previously published program for nonlinear regression analysis of serum drug concentrations which can utilize data obtained during multiple-dose administration is described. Specific programs were developed for aminoglycosides [e.g., amikacin], digoxin and theophylline. The programs provide initial parameter estimates (for a 1-compartment linear model) for each drug based on mean population parameters and refined estimates based on observed concentration data. Clinical examples which demonstrate the flexibility of these programs are provided. The programs may also be employed for fitting data for any drug that can be adequately described by a 1-compartment linear model.This publication has 4 references indexed in Scilit:
- Numerical Integration Simulation Programs for the MicrocomputerTherapeutic Drug Monitoring, 1980
- Forecasting individual pharmacokineticsClinical Pharmacology & Therapeutics, 1979
- Pharmacokinetics of dosing regimens which utilize multiple intravenous infusions: Gentamicin in burn patientsJournal of Pharmacokinetics and Biopharmaceutics, 1976
- Improved Computer-Assisted Digoxin TherapyAnnals of Internal Medicine, 1975