Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract
- 7 January 2007
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 13 (2) , 147-149
- https://doi.org/10.1038/nm1529
Abstract
Poor human-to-human transmission of influenza A H5N1 virus has been attributed to the paucity of putative sialic acid α2-3 virus receptors in the epithelium of the human upper respiratory tract, and thus to the presumed inability of the virus to replicate efficiently at this site. We now demonstrate that ex vivo cultures of human nasopharyngeal, adenoid and tonsillar tissues can be infected with H5N1 viruses in spite of an apparent lack of these receptors.Keywords
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