Inhibition of lipid peroxidation by ubiquinol in submitochondrial particles in the absence of vitamin E
- 8 July 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 285 (1) , 39-43
- https://doi.org/10.1016/0014-5793(91)80720-n
Abstract
The relationship between the antioxidant effects of reduced coenzyme Q10 (ubiquinol, UQH2) and vitamin E (α‐tocopherol) was investigated in beef heart submitochondrial particles in which lipid peroxidation was initiated by incubation with ascorbate + ADP‐Fe3+. These effects were examined after extraction of coenzyme Q10 (UQ‐10) and vitamin E from the particles and reincorporation of the same components alone or in combination. The results show that UQHZ efficiently inhibits lipid peroxidation even when vitamin E is absent. It is concluded that UQH2 can inhibit lipid peroxidation directly, without the mediation of vitamin E.Keywords
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