Radiation-Induced Sarcoma Following Radiotherapy for Testicular Tumor

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Abstract
Four [human] cases of soft tissue sarcoma following radiation therapy for testicular tumor are reported. The tumors included leiomyosarcoma, fibroxanthosarcoma, reticulum cell sarcoma and spindle cell sarcoma. Each malignancy arose within the irradiated area after a long latent period (mean 12 yr) and each was histologically proved. Total radiation doses ranged from 3500-9000 rad. Three patients died as a result of the 2nd neoplasm. Radiation-induced sarcomas are rare but must be considered in the differential diagnosis of new tumor growth in patients treated previously with radiotherapy. Full evaluation of such new tumor growth, including tissue diagnosis, is necessary before additional therapy is prescribed.