A double-blind clinical trial in weight control. Use of fenfluramine and phentermine alone and in combination

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Abstract
A double-blind, controlled clinical trial was performed comparing phentermine resin (30 mg in the morning), fenfluramine hydrochloride (20 mg 3 times/day), and a combiantion of phentermine resin (15 mg in the morning) and fenfluramine hydrochloride (30 mg before the evening meal) and placebo. Low doses of the 2 drugs were combined to maintain efficacy while diminshing adverse effects. People (81) with simple obseity (130 to 180% ideal body wt) participated. Individualized diets were prescribed and discussed again during the 24-wk study period. Weight loss in those receiving the combination (8.4 .+-. 1.1 kg; mean .+-. SEM [standard error of the mean]) was significantly greater than in those receiving placebo (4.4 .+-. 0.9 kg; Scheffe''s test) and equivalent to that of those receiving fenfluramine (7.5 .+-. 1.2 kg) or phentermine (10.0 .+-. 1.2 kg) alone. Adverse effects were less frequent with the combination regimen than with other active treatments. Participants (37) dropped out of the study, 18 for reasons related to drug treatment. Combining fenfluramine and phentermine capitalized on their pharmacodynamic differences, resulting in equivalent weight loss, fewer adverse effects and better appetite control.

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