Protein Kinase in Adipose Tissue: Effect of Hypophysectomy
- 1 January 1974
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 6 (02) , 146-150
- https://doi.org/10.1055/s-0028-1093880
Abstract
Hypophysectomy was found to decrease the cAMP-dependent and independent protein kinase activity in adipose tissue and isolated adipocytes, as observed with protamine or histone substrates. Hypophysectomy did not affect the sensitivity of protein kinase to cAMP at various nucleotide concentrations. Adipose tissue was shown to contain a considerable phosphoprotamine phosphatase activity which was not affected by hypophysectomy. The data presented suggest that the decreased protein kinase activity may be, at least partly, responsible for the decreased cAMP-induced activation of lipase in adipose tissue of hypophysectomized rats.Keywords
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