TREATMENT OF OSTEOGENIC-SARCOMA .2. AGGRESSIVE RESECTION OF PULMONARY METASTASES
- 1 January 1979
- journal article
- research article
- Vol. 63 (5) , 753-756
Abstract
Patients (39) with osteogenic sarcoma were treated in a prospective protocol involving the use of adjuvant high-dose methotrexate, frequent screening for pulmonary metastases, and aggressive resection of all metastatic disease whenever possible. Of these 39 patients, 22 have had recurrence and in 20 patients evidence of metastatic disease was confined to the lungs. Eighteen of the patients had thoracotomy, and in 11 patients all known disease was resected. Although 4 of these patients have required further thoracotomies, all 11 patients have no evidence of disease. Thus, of the original 39 patients, 30 (76.9%) are now alive and 28 (71.8%) have no evidence of disease, with a median followup of 27 mo. Survival is significantly improved compared to historical control patients (P = < 0.001; one-sided Kruskal-Wallis test).This publication has 3 references indexed in Scilit:
- TREATMENT OF OSTEOGENIC-SARCOMA .1. EFFECT OF ADJUVANT HIGH-DOSE METHOTREXATE AFTER AMPUTATION1979
- Chemotherapy and thoractomy for metastatic osteogenic sarcoma.A model for adjuvant chemotherapy and the rationale for the timing of thoracic surgeryCancer, 1978
- Suspected pulmonary metastases.Correlation of chest X-ray, whole lung tomograms, and operative findingsCancer, 1977