Reversible Inside−Out Micellization of pH-responsive and Water-Soluble Vesicles Based on Polypeptide Diblock Copolymers
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- 28 January 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (7) , 2026-2027
- https://doi.org/10.1021/ja043920g
Abstract
The synthesis of a new zwitterionic diblock copolymer poly(l-glutamic acid)-b-poly(l-lysine) (PGA-b-PLys) is described, and its self-assembly into schizophrenic vesicles that can reversibly be produced in moderate acidic or basic aqueous solutions is reported. These pH-sensitive nanoparticles are expected to be very promising candidates in macromolecular nanobiotechnologies.Keywords
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