Lipoprotein Changes after Burn Injury in Man

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Abstract
Lipoprotein changes were investigated in 16 patients with burn injury. Serum, urine and blister fluid were examined for apoprotein content. In the group of patients with moderate burns, serum high density lipoprotein (HDL) fell drastically, and low density lipoprotein (LDL) decreased slightly, while very low density lipoprotein (VLDL) rose. In blister fluid there was a greater loss of HDL apoprotein than LDL apoprotein or apoprotein C, while in concentrated urine a small quantity of HDL apoprotein could be detected. The loss of HDL, which is necessary as an apoprotein C receptor in the conversion of VLDL .fwdarw. LDL, may lead to a block in the conversion of VLDL to LDL. This may in part contribute to the hypertriglyceridemia, hypocholesterolemia and hypophospholipidemia noted after burn injury.

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