High-Level Chloroquine Resistance ofPlasmodium falciparumMalaria Acquired in Kenya
- 16 December 1982
- journal article
- case report
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 307 (25) , 1560-1562
- https://doi.org/10.1056/nejm198212163072506
Abstract
RESISTANCE to chloroquine in Plasmodium falciparum malaria has become a serious threat to the health of travelers to East Africa. We report here a case of cerebral malaria due to P. falciparum infection acquired in Kenya by a tourist who was receiving routine chloroquine prophylaxis. In addition, despite therapy with a standard curative dosage of chloroquine, the patient's parasite density increased, and her clinical status deteriorated. This case expands the recognized spectrum of chloroquine resistance in P. falciparum infections from East Africa, and along with other cases representing lesser degrees of resistance1 2 3 4 5 6 7 8 9 10 has prompted the revision11 of recommendations12 , 13 for the . . .Keywords
This publication has 12 references indexed in Scilit:
- CHLOROQUINE-RESISTANT FALCIPARUM MALARIA IN SEMI-IMMUNE NATIVE AFRICAN TANZANIANSThe Lancet, 1982
- Determination of chloroquine and its desethyl metabolite in plasma, red blood cells and urine by liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1982
- Chloroquine-resistant falciparum malaria in Madagascar and KenyaPathogens and Global Health, 1981
- Serum concentrations of chloroquine in a patient with a late recrudescence of Kenyan Plasmodium falciparum malariaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1981
- Plasmodium falciparum in Vitro: Determination of Chloroquine Sensitivity of Three New Strains by a Modified 48-Hour TestThe American Journal of Tropical Medicine and Hygiene, 1980
- Ein Fall von Falciparum-Malaria mit Chloroquin-Resistenz (R1) von den ostafrikanischen Komoren-InselnInfection, 1980
- CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM EAST AFRICA:The Lancet, 1979
- Chloroquine-Resistant Falciparum Malaria From AfricaJAMA, 1979
- Chloroquine-resistant Plasmodium falciparum malaria in KenyaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1979
- Human Malaria Parasites in Continuous CultureScience, 1976