High-Level Chloroquine Resistance ofPlasmodium falciparumMalaria Acquired in Kenya

Abstract
RESISTANCE to chloroquine in Plasmodium falciparum malaria has become a serious threat to the health of travelers to East Africa. We report here a case of cerebral malaria due to P. falciparum infection acquired in Kenya by a tourist who was receiving routine chloroquine prophylaxis. In addition, despite therapy with a standard curative dosage of chloroquine, the patient's parasite density increased, and her clinical status deteriorated. This case expands the recognized spectrum of chloroquine resistance in P. falciparum infections from East Africa, and along with other cases representing lesser degrees of resistance1 2 3 4 5 6 7 8 9 10 has prompted the revision11 of recommendations12 , 13 for the . . .