Improved Preparation of Enantiomerically Pure 5-Oxo Amino Acid Derivatives by Palladium-Catalysed Coupling Reactions
- 1 August 1995
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1995 (08) , 819-820
- https://doi.org/10.1055/s-1995-5092
Abstract
The organozinc reagent 3 reacts with unfunctionalised acid chlorides under palladium catalysis to give enantiomerically pure protected 5-oxo amino acids in good to excellent yields, provided dimethoxyethane (DME) is used as solvent. For functionalised acid chlorides, the solvent systems benzene/dimethylacetamide (DMA) or toluene/DMA are preferred.Keywords
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