Aluminum — Much Ado about Something

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Abstract
Aluminum was first used to control phosphate levels in patients undergoing dialysis 30 years ago, after Dr. Belding Scribner noted that his early patients on dialysis were "turning to stone"1 (and Scribner BH: personal communication). As phosphate levels fell in response to oral aluminum salts, the tumorous calcium phosphate deposits melted away. From these observations came the concept of monitoring the calcium phosphate product and the recognition of the need for phosphate binders.Twelve years ago concern was expressed about the toxicity of parenteral aluminum when it was discovered that a virulent dementia, as well as fracturing osteomalacia, was associated . . .