Serum Creatine Phosphokinase Activity in Newly Admitted Chronic Alcoholics

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Abstract
Serum CPK [creatine phosphokinase] activity was measured for 33 cases of chronic alcoholics admitted to a mental hospital. The results were examined in relation to the manifestation of the psychotic symptoms in the patients. Increased serum CPK activity was shown in 78.8% within 48 h of admission. In most cases that showed abnormal CPK activity, CPK value was the highest at admission, and after 1 or 2 wk settled to the normal CPK level. There was a positive correlation between abnormal CPK activity and the manifestation of the psychotic symptoms in the mo. before and after entering hospital. Of those having more than 101 IU in serum CPK value, the rate of presenting the psychotic symptoms in 1 mo. before or after admission was 90.5% and 71.4%, respectively.