PRODUCTION AND CATABOLISM OF CORTISOL FOLLOWING THE ADMINISTRATION OF THYROXINE ANALOGS123

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Abstract
Permanent cannuals were placed in the adrenal veins of dogs and minute cortisol output was measured prior to and following injections of triiodothyroacetic acid, triidothyronime and thyroxine. Cortisol output was increased within 30 to 120 minutes after the injection of the thyroxine analogs, but not after thyroxine, to the same extent as that found in control animals given corticotropin. The adrenal response to thyroxine analogs could not be obtained in hypophysectomized dogs. Infused cortisol disappeared from the plasma at a more rapid rate in dogs pretreated with triiodothyronine than in controls. It is suggested that the rate of peripheral steroid metabolism is increased due to the thyroxine analogs, which in turn stimulates the release of corticotropin.