Site of the ganglion blocking action of gardneramine and hirsutine in the dog urinary bladder in situ preparation.

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Abstract
The ganglion blocking site of gardneramine (GA) and hirsutine (HS) was studied in the dog urinary bladder in an in situ preparation. GA and HS selectively inhibited the DMPP[dimethylphenyl-piperazinium]-induced contraction without having an antagonistic effect on the McN-A-343[chlorophenylcarbamoyloxybutyryltrimethylammonium]-induced and acetylcholine-induced contraction. Since GA and HS showed a local anesthetic action weaker than that of procaine, the effect of procaine was studied on the same preparation. Procaine inhibited the McN-343-induced contraction, and it slightly inhibited the DMPP-induced and acetylcholine-induced contraction. GA and HS evidently inhibited the ganglionic transmission of the dog urinary bladder, and the blockade of the nicotinic receptor played a main role.