Genetic aspects of the Pi system
Open Access
- 1 June 1974
- journal article
- research article
- Published by Oxford University Press (OUP)
- Vol. 50 (584) , 362-364
- https://doi.org/10.1136/pgmj.50.584.362
Abstract
α1-Antitrypsin can be shown to be polymorphic by starch gel electrophoresis. At present 19 different alleles are known which are inherited in an autosomal pattern and constitute the Pi system. In one phenotype called Pi type ZZ there is a virtual deficiency of plasma α1-antitrypsin and about 230 such babies are expected in England and Wales every year.Keywords
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