Assessment of the Carbon Tetrachloride-lnduced Cirrhosis Model for Studies of Nitrogen Metabolism in Chronic Liver Disease
- 1 January 1994
- journal article
- research article
- Published by S. Karger AG in Annals of Nutrition and Metabolism
- Vol. 38 (4) , 238-248
- https://doi.org/10.1159/000177817
Abstract
We evaluated the rat cirrhosis model obtained by repeated intraperitoneal administration of CCl4 (group C) with regard to biological and nutritional conditions in comparison to ad libitum (group AL) and pair-fed control rats. Cirrhotic rats were divided into two groups according to their clinical condition: group C1 (n = 4) represented those in good physical condition and group C2 those (n = 10) in poor physical condition. Autopsy indicated that rats in group C2 suffered from severe malnutrition as judged by body weight, carcass weight and the carcass/body weight ratio. However, all 14 treated rats presented the same micronodular cirrhosis and the same alterations in liver function, except for alkaline phosphatase activity (group C1: 110 ± 63 IU/1, group C2: 259 ± 110 IU/1; pKeywords
This publication has 0 references indexed in Scilit: