Non-Hodgkin lymphoma of the testis.

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Abstract
Sixteen patients (median age, 67 yr) with non-Hodgkin lymphoma of the testis were studied. Twelve of these patients had disease that was classified as local (stages IE and IIE). Eight patients had diffuse histiocytic lymphoma, 6 had diffuse poorly differentiated lymphocytic lymphoma, 1 had both lymphoma and seminoma and 1 had nodular poorly differentiated lymphocytic lymphoma. The overall median survival was 9.5 mo. Para-aortic nodal involvement was the factor that had the strongest prognostic influence with the management methods used. Median survival without para-aortic nodal involvement was 57+ mo.; with such involvement it was 6 mo. (P = 0.002). There is a high probability of generalized disease if lymphoma can be detected in the para-aortic nodes. For patients with stages IE and IIE disease, radical radiation therapy is the preferred treatment. For those with disseminated disease, chemotherapy, with irradiation reserved for symptomatic and bulky localized deposits is the recommended method of management.