Abstract
The epidermal DNA has been determinated cytophotometrically in clinically not-involved psoriatic skin, separate in stratum basale, the lowest three layers and the upper part of stratum spinosum. 1. The DNA patterns differ in all layers from those in normal epidermis. 2. The number of nuclei with hyperdiploid values is in all the stratum spinosum higher than in normal skin. 3. The importance, possible due to these findings, for the run down of the psoriatic reaction is discussed.

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