Neonatal hepatitis and extrahepatic biliary atresia in the same sibship.

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Abstract
A rare case of neonatal hepatitis and extrahepatic biliary atresia in the same sibship is reported. The older brother with neonatal hepatitis developed jaundice at the age of 4 days and had clay-colored stools from early infancy. Cholangiography by exploratory laparotomy at the age of 3 mo. showed a normal bile duct pattern. After laparotomy, jaundice rapidly disappeared and the stools became yellow. His liver function has been normal since the age of 6 mo. to the present (6 yr old). The younger brother developed jaundice and clay-colored stools at the age of 1 mo. The diagnosis of extrahepatic biliary atresia was made at laparotomy at the age of 4.5 mo. Hepatojejunostomy was performed with successful bile drainage, although he had frequent attacks of ascending cholangitis since the operation. Neonatal hepatitis and extrahepatic biliary atresia may be produced by the same disease process.