PH1-POSITIVE CHILDHOOD LEUKEMIAS - SPECTRUM OF LYMPHOID-MYELOID EXPRESSIONS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 49  (4) , 549-558
Abstract
Two children presented with Ph1[Philadelphia chromosome]-positive leukemia, confirmed by Giemsa banding as 22q-. One child showed an initial presentation characteristic of acute lymphoblastic leukemia, followed by development of chronic myelocytic leukemia 2 yr later. A 2nd child presented in blast crisis. Both patients showed blast cells possessing lymphoid and myeloid characteristics, as demonstrated by histochemical, biochemical or surface receptor properties of each cell series. The evidence provided supports the assumption of mixed lymphoid-myeloid properties of blast cells in chronic myelocytic leukemia in children. Detailed study of the leukemic cells may aid in the understanding of complex stem cell relationships and suggest more effective therapeutic approaches.

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