Aging effect on the noradrenaline content of rat brain microvessels

Publisher Website
Google Scholar
Abstract
Microvessels were isolated by sucrose gradient centrifugation and molecular seiving from forebrains of aged and young adult male Sprague-Dawley rats. Determination of noradrenaline levels in preparations obtained from both groups of animals indicated that the level of NA in cerebral microvessels isolated from aged animals (120 ± 28 pg NA/mg protein) was significantly reduced when compared with the corresponding value from control (young adult) animals (226 ± 35 pg NA/mg protein). This decrease in NA may indicate a deficiency in the neural control of the microcirculation and predispose to metabolic and functional disturbances of brain tissue.