Effects of prostaglandins E1 and E2 on human, guinea‐pig and rat isolated small intestine

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Abstract
1 . Prostaglandins E1 and E2 contracted the longitudinal muscle of human, guinea-pig and rat isolated ileum. 2 . The site of action varied with the species. In the rat and in some strips of human tissue prostaglandin appeared to have only a direct action on or in the muscle cells. In the other strips of human tissue and in guinea-pig ileum the prostaglandins seemed to stimulate both the intrinsic cholinergic nerves and the muscle cells. 3 . In contrast to the longitudinal muscle, the circular muscle of human, guinea-pig and rat isolated ileum was usually inhibited by prostaglandin, apparently by an action directly on the muscle cells. 4 . Prostaglandins may play a part in the control of intestinal motility.