SINGLE POINT ESTIMATION OF PHENYTOIN DOSING - A REAPPRAISAL

  • 1 January 1981
    • journal article
    • research article
    • Vol. 34  (2) , 231-239
Abstract
A previously proposed method for estimation of phenytoin dosing requirement, using a single serum sample obtained from humans 24 h after i.v. loading dose (18 mg/kg), was re-evaluated. Using more realistic values for the volume of distribution of phenytoin (0.4-1.2 l/kg), simulations indicate that the proposed method will fail to consistently predict dosage requirements. Additional simulations indicate that 2 samples obtained during the 24-h interval following the i.v. loading dose could be used to more reliably predict phenytoin dose requirement. Because of the nonlinear relationship which exists between phenytoin dose administration rate (RO) and the mean steady state serum concentration (CSS), small errors in prediction of the required RO result in much larger errors in CSS.

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